TREATMENT OF HEMATOLOGICAL MALIGNANCIES WITH LAMINAR AIR FLOW ROOM

Treatment of Hematological Malignancies with Glycyrrhizic Acid.

The current study examined the effectiveness of glycyrrhizic acid (GA) in reducing cell viability and inducing apoptosis in human chronic myeloid leukemia (CML) in vitro and a mouse lymphoma in vivo. Additionally, we assessed GA as a candidate for combinational therapy in CML along with the current frontline treatment, imatinib (IM). Treatment of K562 CML cells with GA alone resulted in signifi...

The effect of laminar air flow and door openings on operating room contamination.

We evaluate the association of laminar airflow (LAF) and OR traffic with intraoperative contamination rates. Two sterile basins were placed in each room during 81 cases, one inside and one outside the LAF. One Replicate Organism Detection and Counting (RODAC) plate from each basin was sent for culture at successive 30-minute intervals from incision time until wound closure. At successive 30-min...

A perspective on OR laminar air flow.

Antifungal prophylaxis and treatment in patients with hematological malignancies.

Invasive fungal infection (IFI) is a serious and common complication in hematological patients. The risk is highest among acute leukemia patients undergoing induction chemotherapy and patients undergoing allogeneic hematopoietic stem-cell transplantation. Owing to the difficulty in diagnosing IFIs and the fatality rate associated with delayed treatment, antifungal prophylaxis and empirical anti...

Platelet support of patients with hematological malignancies.

The most significant advances in platelet transfusion therapy for oncology-hematology patients can be summarized as follows: 1) prophylaxis versus treatment of hemorrhage. Usual practice is based on hemorrhage prophylaxis. Debate is still open on the transfusion trigger, which is traditionally set at 20 x 10(9)/L platelets: some authors suggest it could safely be decreased in stable patients to...